Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)-
GKI-1
CAS: 2444764-03-6
Molecular Formula: C15H12ClN3
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- - Names and Identifiers
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- - Physico-chemical Properties
| Molecular Formula | C15H12ClN3 |
| Molar Mass | 269.73 |
| Density | 1.320±0.06 g/cm3(Predicted) |
| Boling Point | 504.5±45.0 °C(Predicted) |
| pKa | 13.93±0.50(Predicted) |
| Storage Condition | 2-8°C，惰性气体保存 |
| In vitro study | GKI-1 inhibits full-length human GWL, and shows cellular efficacy. Treatment of HeLa cells (25 and 50 µM, 0-8.5 hours) with GKI-1 reduces ENSA/ARPP19 phosphorylation levels, resulting in a decrease in mitotic events, mitotic arrest/cell death and cytokinesis failure. |
Benzenamine, N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)- - Reference Information
| biological activity | GKI-1 is a great wall (GWL) kinase inhibitor, the IC50 for the inhibition of hGWLFL and hGWL-KinDom were 4.9 and 2.5 μm, respectively. GKI-1 can effectively inhibit ROCK1,IC50 is 11 M, only a weak inhibition of PKA. |
| Target | IC50: 4.9 µm (hGWL FL ), 4.9 µm (hGWL-KinDom) |
Last Update：2024-04-09 21:32:11
